[EP.16]Enzyme Secrets Unlocking the Key to a Longer, Healthier Life


Dr. Joel Rosen:
All right, so today I’m joined by Jeff Owen. He has been an ASD enzyme US retail private label practitioner educator trainer since 2021. He’s worked in the natural industry for over three decades and I’m really interested to know Ask him about his experiences. And he represented a number of large supplement supplement manufacturers. And I told Jeff before we get started, we’d want to hear about sort of The Good, the Bad, and the Ugly if he’s willing to tell us about all that. But without further ado, Jeff, thank you so much for being here today.

Jeff Owen:
Dr. Rosen, thank you so much for having me as your guest. I really feel privileged. Oh, good. Well, listen,

Dr. Joel Rosen:
I’ve had some guests in the past where their same position as you and I, and I’m always interested to hear about your experiences, and most importantly, what the listener can glean from that to help their own health journey and feel younger at heart and younger physically, mentally, emotionally. So Jeff, what tell me just give us sort of an overview of, why you got into this industry, you were telling me you have a sort of a unique background in your health journey.

Jeff Owen:
So in terms, in terms of the chronology, of how the company makes the enzyme and probiotic products, the raw materials themselves were made in Mumbai, India, and then they’re shipped to Chino, California, where there are four NS-certified manufacturing facilities, the first of which opened in 1985.

And as you can imagine, what our company is committed to is rigorous rigorous testing. So the products are tested, tested, tested, and set at a GMP-certified facility. And then the fermentation, the extraction, the blending, the formulating all that is done at in Chino, California. And what I like about this company, Dr. Rosen is that they’re not trying to be all things to all people. In other words, this company, their, their, the mission of this company, is to be a pre-eminent science manufacturing company.

And of course, the challenge for any company that’s involved with nutritional manufacturing, supply manufacturing, is to get the science, if you will, the pure science and apply it, you know, commercially, if you will, so that they’re linked together. And they were aligned. And I feel like of all the companies that I’ve had the opportunity to work with, in 30 plus years in the natural products industry, this company does it as well as anybody.

Dr. Joel Rosen:
Yeah, well, there, you said a lot there, which is, which is interesting. So a couple of things that I would want to touch upon is obviously enzymology. And that’s the purpose of our call today, and what that is and what enzymes are and how they differ from digestive purposes and systemic, like breaking down the purposes which we’ll get to in a second, I have seen that I’ve had another interview with the guests and talking about how some of these companies that were privately got sold to pharmaceutical companies and the concern with the I guess the goal of the company, does it change in terms of providing the best quality or are they trying to cut corners and get the cheapest product and make a higher profit.

Also, the concern is that he did the other guests talked about how you get a trade-off, you can be darn sure that the the cleanliness of the lab and making sure that they are getting quality control in there is going to be top-notch, but at the same time is the products going to be top notch.

So thank you for sharing your insight with your new company. Just before we get into the enzymes, and what they are one of the questions I like to ask guests is that we talk about supplements and the the purity of their products and the the emphasis that goes into the quality right from sourcing it themselves. I had the privilege of going through a lab and I liked that they teach this or they emphasize this to their sales reps because they need to know that their quality of the product that they’re representing is of the highest quality so that you feel good about what you’re promoting to other people.

So with that being said, I had a chance to walk through a lab that is a supplement company that does the same thing or has the same emphasis. I guess the question to you Jeff is the they use the what’s the name of the just last off the top of my head but they will it is a way that they scan the products to fo photometry or how they

Jeff Owen:
Go to liquid chromatography or HPLC. Yes.

Dr. Joel Rosen:
So thank you. So maybe I’m sure they use that to tell our listeners what that is and how that’s able to discern the quality of the product with purities, or impurities if that’s being used or not, or also with another concern that I typically have is they’ll use a lot of flow through agents that will have some excipients in there that are told, Well, it’s not that much of a problem, or you shouldn’t worry about it, but in the reality is, if you’re taking a supplement over and over and over and over again, could it be more of a problem than something that’s just benign and not problematic? So sort of twofold question. Does the company use that? And how about excipients in the products

Jeff Owen:
in terms of the company’s, like you said, commitment to following you know, the highest, you know, regulatory analytical protocols. I, you know, I’ve been to the facility in Chino, California, on two occasions, I wish had, if I lived closer, obviously, I wouldn’t have more access to the facility, I would probably have more of an intimate, you know, knowledge about this, but what I can say is this, with respect to the in the analytical protocols, you know, that the company follows, they are always using the most advanced protocols, including high photo liquid chromatography. You know, enzymes are, are precision-based manufacturing, and it does take a real deep understanding, to make enzymes.

The interesting thing is often, when you, you know if you’re a consumer and you’re in a health food store, trying to discern, you know, what is a high-quality enzyme supplement. One of the things like you said, you look at is not just the active ingredients, but the excipients that are used or flow agents, with ASP enzymes as much as possible. The formulas use minimal, minimal amounts of excipients or flow agents.

So typically, if you’re looking at any one of our products, you know, one thing you will see, of course, is that the capsules themselves are made from vegetarian cellulose. And we use in some occasions, you know, just Manute really, the finished product is nearly undetectable. You know, flow agents such as, um, actually, we don’t eat at one time, I think we were using silicon dioxide, but we don’t use that anymore.

In the last year, though, we did list it on the label. And because we want to be a transparent company, that we do use as a medium, you know, to grow the bacterium that makes the enzymes that we do use maltodextrin. But now that put them out of dextran that we use from wood is a corn source, but it is non-GMO. And the finished product of the resulting product, the amount of maltodextrin that’s in there is minute, minuscule, nearly undetectable.

The interesting thing is that every company that is involved in the enzyme Manufacturing Practice has to use some type of a medium, a growth factor to make the bacterium. And when they don’t list it, it’s somewhat disingenuous. But this is something as a company that we made a decision, you know, make sure that the labels indicated that because we want to also be fully compliant with the law, the dietary supplement Health and Education Act.

And of course, you know, like with anything else, you know, science, I would like to say it’s not dogmatic, it’s ever-changing. And we, as a company, always look to make, you know, changes. I’ll give you one other example, too. From a manufacturing perspective. Dr. Rosen, I think truly, truly distinguishes us. with ASD enzymes, we actually are the preeminent serrapeptase manufacturer, we manufacture 80% of serrapeptase. And we’ll maybe have the opportunity to talk about that later.

But one of the things that we understand about serrapeptase enzyme is that it’s extremely hydrophilic and various, very susceptible to the low stomach acid environment. So when you take it the question is always how much ultimately are you absorbing through the small intestine through the small intestine?

And we understand because it’s very, very sensitive nature, that you have to have some type of a protect, you know, protection. And it’s this, you know, series of ways to protect serrapeptase you could use you could use a moat. In, our case, we use an enteric coating, other companies might use micronized. Features, but, when you pick up a product of serrapeptase, and it’s and it doesn’t say that it’s enteric coated, it really is an open question of how much of it the body is actually utilizing absorbing.

So in our case, we use a trademarked enteric coating that is free of phthalates, polymers acrylics, we actually spray the serrapeptase material, not the capsule itself, so that therefore you’re getting, you know, the full activity when it gets into the small intestine. then. And that’s important too, because obviously when people are taking an enzyme such as that, for a variety of health conditions, people want to obviously get the intended benefits associated with this. So that’s the thing that not trying to play that fast and loose with the manufacturing or trying to maybe give people a misleading impression that something, you know, maybe unsafe when the reality is that it is safe.

Dr. Joel Rosen:
Yeah, well, the liquid spectrometer, I think, is really important that I don’t know how many companies actually use it. But I think that it’s able to give you an identification of what ingredients are in there, and what impurities or what other types of toxic mold or other types of metals or things that people have to really be aware of.

And when you’re talking about enzymes, which we’ll talk about why enzymes, why are we talking about enzymes in the first place, but when you’re talking about enzymes, I would agree, you have to have some kind of medium to create that bacteria naturally so that it’s going to be able to break down and be able to be utilized. So that’s a good segue what, you know, for the listener, who most of our listeners are sophisticated, but if they just want to have a, a recap of what actually are enzymes, and how do they work, maybe kind of get into that,

Jeff Owen:
that’s a good place to start. Um, enzymes are a are defined as protein catalysts. And they are made up of amino acids. And just as proteins generally are, and their main function is to act as a biocatalyst, that’s the term you often use with respect to enzymes. They act as bio catalysts to spark chemical reactions in the cells of living organisms, from bacteria to humans. Presently, we understand there are more than 5000 biochemical reactions that are directed by enzymes.

And probably the most classic examples that people would understand is breaking down, let’s say starches and proteins in the digestive tract, and the digestive system, I should say, coercing muscles to contract, or promoting cell signaling, regulating your metabolism.

And more recently, this has really been fascinating Dr. Rosen, because I read a book, you may have read this book yourself, it came out about two or three years ago called Breaking the code, about this whole research regarding genetic testing and editing, the CRISPR project. And what they have found is that enzymes also are involved in splicing and dicing, if you will, RNA and DNA. So truly, truly, enzymes are truly profound.

And they’re unique. Enzymes, because they’re bio, they are unique, because they are biologically active, meaning they contain energy. And it’s the energy that makes it possible for the enzymes to perform the roles that they do in the human body, the work of life, I like to say, so the enzyme that so the energy that can take that is contained in enzymes, that should be noted, though, it’s not unlimited, they will go on and on and on and on. Until they get to a point where they no longer have any biological activity. And then at that point, it ceases being a catalyst.

And because like any other protein, they will be absorbed by the body. But every biochemical reaction, again, that is taking place in the human body is directed by enzymes, which is why I think they play such a profound role in human nutrition. There are two different types of enzymes, the one that is probably most familiar to people is digestive enzymes, of course, these are enzymes that are involved in the digestion of food, the assimilation of nutrients, and the elimination of nonessential toxic ingredients in the body.

Less familiar to the audience, or what I refer to as systemic or affiliate terms, that’s more probably uses Metabolic Enzymes, which are involved in all the vital processes taking place within the 100 trillion cells that are in the human body. So they provide the metabolic energy, if you will, that, ultimately allows us to see here think, walk, and talk.

And I always like to say simply put, you know that enzymes, you know, life wouldn’t, would cease to exist. function, the thing we also really understand about enzymes is that because they are involved in energy, you know, without them, yes, you could imagine there’s no living organism could exist, if you have to just hope, you know, spontaneously that, you know, biochemical reactions, you know, would take place.

Obviously, that’s just, there’s no way that any kind of living organism, you know, from an evolutionary standpoint, could adapt to that. So this process is literally going on, you know, quicker than the wink of an eye, on and on and on and on and on. And the other thing that we understand about enzymes, and this is a term that’s often used as they have what’s called specificity, meaning they have a specific specific role. So for instance, like enzymes that will break down proteins proteases are not going to work on breaking down fats, those are enzymes referred to as lipases.

In some cases, they have similar roles. But they’re different. I always like to say, if you could use an analogy, you wouldn’t, you wouldn’t use like a half-inch wrench to try to put in a, you know, like a one-inch screw, you will try and try and try to make it work, but it won’t fit. And that’s how it is with enzymes, they may look, and they may have similar functionalities and structures. But literally, one enzyme will do a specific role in breaking down a protein, and another enzyme will come in and do that. So it’s like a chain reaction that’s going on all the time in the human body.

Dr. Joel Rosen:
Well, that’s great. And I will look up the breaking the code, I haven’t read that. And I don’t know if you know, I do, one of the things that I do is I do a lot of genomic test interpretations, which means they either have the raw data from different companies, or we have a kit that we we promote, people are always concerned about giving their their DNA information to out there in the public.

So we have safety measures, and we don’t use the big clearing houses and so forth. So anyway, that’s a whole other side. But when we look at those different 23,000 genes, what they’re doing is they’re coding for enzymes. So I use the example of credit to a lot of people. It’s funny, Jeff, on that older generation, where I say, Well, it’s the analogy is kind of like when you put your credit card in the credit card machine, and you do like this, and you get it and people look at me like what the heck is that?

What is it? So another analogy I use as well think about is if you put a piece of paper in the photocopying machine, and it’s either moving or it goes in there sideways. And it’s not able to create a good replica of what GNA is doing in its coding for enzymes. And these enzymes are very important for cellular processes in the body, for being able to make an energy to be able to break down tissue, to be able to deal with stress, to be able to detox to be able to, you know, basically create your neurochemicals.

So they are responsible for every phase of your body. So thank you for sharing that. As far as digestive enzymes go, not all enzymes are created equal. And there are different forms of enzymes, I guess, going from there. There are systemic enzymes as far as other places. And I like that term. I don’t think I’ve actually heard about the term Metabolic Enzymes versus systemic enzymes. And so I guess I’d like to know your insight on what is systemic systemic enzyme therapy, that the ASD labs have focused on. You mentioned serrapeptase and having 70 to 80% of the production, what exactly are the areas that systemic enzymes that your company produces, focus on? What are their sort of the goals of the products they’ve produced?

Jeff Owen:
Yes, the thing that people need to understand is that, unlike digestive enzymes, Metabolic Enzymes are, are used in the human body, you know, for detoxification, as you said, breaking down tissues on tissues that are unwanted or unhealthy, necrotic tissue, obviously, boosting our body’s immune system wasn’t making our adaptive immune system work better, that what’s interesting is that the endogenous Metabolic Enzymes are very, very difficult to manufacture from a commercial basis.

Otherwise, we would probably see them quote unquote, in health food stores or in therapeutics. But what we have discovered, though, and ASD enzymes have discovered in six decades of research is that there are these enzymes that are referred to as systemic enzymes that you can get from food sources, well, bacterial sources.

The one enzyme in particular I know people are probably very familiar with is bromelain enzyme, sometimes referred to as protein stem enzyme, that’s an enzyme that’s known as being proteolytic, meaning it helps the body digest proteins, and you can use but often, you can take it with food to help the body digest protein-based foods, but you can take it away from food to help with conditions like swelling, and inflammation. serrapeptase in answer to your question, fascinating story, Dr. Rosen, it was discovered some decades ago going back to the 1950s in Japan, sometimes it’s referred to as the silkworm enzyme. It turns out that silkworms during their cocoon phase before they become a morph, will make this enzyme in their intestinal tract.

Akt through a bacteria called marcescens bacterium. It produces this enzyme called Soroush to peptidase, sometimes now known by the term serrapeptase. And what they have discovered with serrapeptase. In research studies, going back to the late 1950s is that serrapeptase is a very, very powerful proteolytic enzyme, it seems to have a particular affinity to help with reducing inflammation and has anti-inflammatory and analgesic properties. It’s also known as an anti-adimec.

It can be particularly helpful for ear nose and throat issues, and respiratory and pulmonary issues. And one of its hallmarks is that it’s involved in scar tissue management and fibrin management. And you know, for those who may or may have heard the term fibrin, sometimes people know about conditions that are fibrotic in nature, like uterine fibroids for women or pulmonary fibrosis. fibrin is an insoluble protein that’s critical for proper blood clotting.

And, and for also helping people fight viruses and bacteria. It’s part of the body’s inflammation process. So it’s critically important. The body makes fibrin through an enzyme called thrombin. From fibrinogen. And, as you can imagine, without without proper blood clotting, you know, if we had a simple cut, we would be you know, we could literally like hemorrhage or bleed.

So clotting, you know, the clotting factor is very, very critical. However having unhealthy fibrin management, which often happens when people’s inflammation response doesn’t resolve itself can be problematic. So one of the hallmarks of serrapeptase is its ability to help dissolve and break down fibrin. And it particularly seems to be helpful when people have a lot of mucus and phlegm conditions.

For conditions like Sinusitis one of the things that people should know is that we have worked with ASTM enzymes, for instance, with the pulmonary fibrosis society, doing collaborative research. Pulmonary Fibrosis could be a serious, if not fatal disorder, where literally the body’s developing, you know, scar tissue in the lungs, and your body’s ability to breathe becomes greatly diminished.

So people who have a lot of excess mucus and phlegm it could be very helpful. What’s interesting about serrapeptase Dr. Rosen, was when the Japanese discovered that it had mucolytic properties, its ability to thin and mucus dislodged mucus, mucus has very viscous and thick, when they analyze the spot of that did spot them conversion studies with these patients who had this these excessive mucus conditions, when they analyze the spot them, what they found is that the neutrophils activity in the spot was high.

And that was the first indication that serrapeptase also seems to play a role in immune modulation, or mitigation. That’s why when I made that reference earlier about cell signaling, that’s kind of what I was referring to. Many people probably in the last few years Dr. Rosen have because of COVID, the advent of COVID have heard this term called you know, a so-called cytokine storm, where the immune system literally, you know, over expresses itself. And the body goes into this hyper-inflammatory state. One of the things that we feel very excited about with serrapeptase is that it has the ability to help modulate the immune response.

But most of the research I will tell you on serrapeptase that has been done thus far, both in vivo and in vitro studies, clinical have been on its ability to help with inflammation, being a natural anti-inflammatory, and analgesic. The last thing I would note about serrapeptase is more recently, there have been some very, very promising studies on serrapeptase being a so-called anti-biofilm agent. And as you probably know, as a doctor, this is becoming a real problem. You know, biofilm is like this nasty biotic, that could really be problematic in hospital and Doctor settings.

It is very difficult to treat even with antibiotics because of the cellular structure, and degree of the membrane of the biofilm. And, you know, of course, we know that we’re almost at an inflection point with antibiotics because of their overuse. But what they found with serrapeptase is that it seems to have the ability to manage biofilm. And that becomes particularly critical because millions of Americans, you know, unfortunately, you know, are on prosthetics, artificial devices, they may be the artificial limbs.

And as you can imagine, when you have artificial devices or prosthetics in the body, it’s always an invitation for unwanted pathogens and bacteria. So, there are studies that we have done. In fact, in 2021, Dr. Rosen, our ASP enzyme submitted to the National Institute of Health an abstract, submitted abstracts showing, you know, the latest research studies on serrapeptase with biofilm is one of the sub-chapters.

The studies have been very promising because serrapeptase seems to help even enhance the effectiveness of the antibiotic. sort of classically used to help treat biofilm. So I think this is something that you’re going to hear more and more about is, as the research continues to evolve.

Dr. Joel Rosen:
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That’s a great insight. Thank you Jeff for sharing that. And I’ve been going down the biofilm rabbit holes now. And I know that there are actually different kinds of biofilms Yes. And you know, bacteria create biofilms, I think they’re showing even viruses create biofilms, and our body creates a biofilm. Depending on the topic, a typical pathogen will depend on the type of biofilm that is produced.

And the reality is okay, so this is an age-reversing blueprint podcast, why are we talking about this? What does this have to do with aging I think the reality is, as we get older specialists are working with anyone now I’d even say over 40, let alone 50 and 60, you just lose the ability to manage your secretions and or make your secretions. And that means that your supply of the juices if you will, I call it milking the cow, your supply of the juices gets depleted. But the reality is your demand for them gets increased, right because of just you’re on the planet longer.

And you get exposed to more toxins and stress and bacteria and communicable diseases and so forth, that your body starts to have a demand and supply problem not just for energy, but for secretions for immune management for bacteria breakdown for biofilm map all of that stuff. And so I think it’s really important that that has to be part of your tool and your toolkit to be able to make sure that you’re digesting your food.

Number one, if you’re not digesting your food, let alone you’re you’re getting older, you’re not getting as much good quality food, you’re not getting as much food in general. And that’s one of the main things I look at it is okay, well, we can go down these genetic rabbit holes, and we can look at your bloodwork.

But the reality is you’re just not, you’re just not converting the little food that you’re getting that isn’t maybe the best nutrients and contaminated and adulterated and maybe it has bacteria or whatever you’re not, you’re not squeezing that and getting the juice out of. And on top of that if you’re not getting the juice out of what’s happening to the foods that aren’t being digested. Right.

So it’s really important to be proactive and reactive and be able to have the digestive secretions, and then be able to have the systemic protocols to help break down some of these fibrin-based bacteria and pathogens that are building up in the body. So with that long-winded recap, is there any concern with taking too much sera peptidase? I mean, let’s just say I go in and I buy a product like yours, and it’s really good. Is there any concern that I didn’t really have a physician look at it, and I’m just taking it and you know what, the more the better? So heck, why not? Tell me Tell us a little bit about that.

Jeff Owen:
That’s a great question. Because, you know, with serrapeptase enzyme being a protein, there is always, you know, the potential risk that someone could be sensitive to a protein, or have a reaction and we do, you know, get these calls every now and then at our office about this with serrapeptase because of the fact that, you know, it is generally speaking not it’s hydrophilic and not greatly absorbed, you know, especially if it’s not, you know, in some type of an enteric coating, or delivery process that protects it, you do usually have to take high amounts of it to realize efficacy.

However, as a company, we always, always recommend serrapeptase because we do sell it by itself and we also have blended Systemic Formulas that you start off with, with a low dosage. So normally we would recommend let’s say with you serrapeptase by itself one capsule a day, preferably on an empty stomach.

The reason why you take serrapeptase away from food either 30 to 60 minutes before eating or two hours after eating is that it’s not competing with the food in your stomach for it to work as you want it to as a proteolytic enzyme. But the idea is to take a small amount just to see what your body’s tolerance to it is.

Usually, after a few days a person hasn’t had an adverse reaction, they can incrementally increase the dosage as warranted. However, what we also do know about serrapeptase is that in addition to it being proteolytic, it is because it’s a proteolytic, anti-inflammatory enzyme. Millions of Americans in the United States are on nonsteroidal anti-inflammatory drugs, it could be a sinner medicine, ibuprofen, or even more severely, you know, corticosteroids like prednisone, cortisone, there are studies suggesting and in fact, we submitted this in the abstract at the NIH, that if you are taking serrapeptase, wants to take syrup ethics, excuse me, but you are presently on some kind of a course of treatment with nonsteroidal anti-inflammatory drugs or corticosteroids, or even more severely, opioids, that the syrup peptides could actually make these drugs more potent.

So it really, it really needs to have that monitored, you know, under the auspices of a physician or practitioner. Because of that, of course, on the converse, the hope is that if the serrapeptase is working, to help reduce, you know, chronic inflammation and pain, that one can then over time wean themselves off or lessen the dosage. But that’s, I think one of the challenges with enzymes, systemically, we don’t really see this with digestive enzymes, per se, but certainly with systemic enzymes like serrapeptase, or natto. kinase is that with certain medications, like with natto kinase, or people on anticoagulant drugs or so-called blood thinners, you always have to be careful about the potential interactions.

So um, you know, these are powerful men, these are powerful supplements. And as you said, they can’t just be taken, you know, willy-nilly. So we do recommend always, you know, we always hope that people follow the label instructions on the label. One of the things I can tell you, Dr. Rosen, you know, kind of going back to the beginning of the broadcast is, in the 30 years, I’ve worked in the natural products industry, I’ve probably talked to 1000s and 1000s of customers in health food stores.

As you can imagine, you get a lot of insights from customers about how in so many cases, their experiences with conventional medicine have been less than stellar. Or just getting contrary advice, feeling that the practitioner doesn’t want to work in partnership with them to follow a more natural Pathak or functional medicine approach. But too often, I think the people that even come in health food stores think that, you know, taking supplements, you know, are just Safe, safe, safe, and that there’s no potential toxicity. But that’s not necessarily always the case.

I mean, you know, with certain supplements, like vitamin D is an example of taking, you know, taking excessive amounts of vitamin E or omega three fish oils. So, we always hope that customers will read the labels that we have. One of the things that we do as a company is we’re a very information-oriented company.

So I know from a consumer standpoint, also when I’m in health food stores working there, we have these wonderful booklets are focused on health booklets, which we have like on five different categories to help one on arthritis, one on diabetes, one of fibromyalgia, heart health, and lastly, pulmonary fibrosis. And those booklets are great because they really give the consumer an insight as to how these supplements work and potential interactions with them.

And with testimonials and the fact that they’re written in such a way that not only can a layperson understand them, but they can’t share them with their practitioner. So it’s Yeah, so it was then with systemic enzymes in particular, you know, it’s always cautionary to start off with a lower dosage. And, you know, and incrementally increase the dosage if the situation warrants it. And hopefully, you want us doing that, like I said, under the auspices of a position like yourself. Yeah,

Dr. Joel Rosen:
well, I think it’s a self-fulfilling prophecy prophecy in this case is that if you’re not just if you’re the, I guess, the weekend warrior, if you will, and you’re going into the nutrition store. serrapeptase isn’t really on your radar unless you’ve done some kind of research to get to that in the first place. But with that being said, I love the fact that the company submits articles and research-based peer reviews I’m interested to know why potentially serrapeptase would make the painkillers and or the anti-inflammatory stronger is that because it’s getting rid of some of the debris so it has more of an open field to bind To receptors to potentiate, the effect of the medication Do you happen to know, I know that I don’t want to put you on the spot. But do you happen to know why it could potentially increase the impact of those types of medications?

Jeff Owen:
Admittedly, I don’t, you did say something that was revealing what one of the hallmarks, of course of systemic enzymes, such as serrapeptase, is their ability, you know, to break down when I call them, you know, cellular debris in the body, whether it’s circulating fibrin, unwanted proteins, circulating immune complexes, you know, all of these things that can trigger the body’s immune system to, you know, to stay in an overactive state, that what’s fascinating about systemic enzymes like serrapeptase, is that when taken on an empty stomach, they can circulate in the bloodstream for up to six to 12 hours targeting areas of need.

So when they make contact with an unwanted protein, you know, like necrotic, tissue, scar tissue, potentially like a cyst, a fibroid, something that’s mutated even a tumor, it goes back to what we were talking about earlier, by their very definition, they’re known as bio catalysts. And they’re going to break down and dissolve the unwanted proteins, ultimately into their amino acid components.

So, therefore, the body can either dispel them outright through your stool or repackage them into healthy protein. So it does seem to be the case with serrapeptase and other proteolytic enzymes, like bromelain, for pain that are kinase, that they can play a complementary and a junk at adjunctive role with other medications. But you’re right, there’s no question. The abstract that we submitted to the NIH said that there’s more research that needs to be done to understand what you know, why these interactions are related to why the serrapeptase makes these, these aspirin type drugs more, more potent. And it could be just as you said, it could have to do with the fact that, you know, its ability to break down and dispel these unwanted proteins.

Dr. Joel Rosen:
Yeah, and chemical signaling. I know also vocal signaling. Absolutely. Yeah. I think that I, and again, I’m just interested, because these are thoughts that are coming off the top of my head, but senolytics and the zombie cells and these misfolded proteins, and these cells that just sort of hang around forever. So there’s this whole new study of senolytic-type cells that break down the senescent cells that just kind of hang there.

Jeff Owen:
I found your podcast about this, it was fascinating. Yeah, well,

Dr. Joel Rosen:
I’m interested to know because there are companies out there that make these quote-unquote analytics. But I would imagine that you could put a systemic enzyme under the category of Sinhala ISIS because it helps to break down some of these, these debris, if you will. So do you know if your company is going towards more of a so lytic complementary role? Or if that’s in the future? Or if senolytics themselves are composed of systemic tech enzymes? Do you know about anything about that? Jeff?

Jeff Owen:
I haven’t heard anything, you know, from from a s t enzymes, about using, you know, senolytics, in combination with systemic enzymes, I am sure, you know, being a science based company, that, that that’s something that they’re always always looking at, you know, as I said earlier, you know, science is an ever evolving adapting field is funnily enough, as somebody who has been, you know, a member of Life Extension Foundation, you know, thinking for years and decades, I know that the whole idea, you know, the whole area of senolytics.

And, as you mentioned, zombie cells and cell senescence is a real real, not just an emerging field, that there’s just a tremendous amount of interest there. I mean, if I were to speculate with my nonscience background, I would think that you know, that they would have a role to play.

Because obviously, the whole idea of being able to help modulate the body’s immune response, helping the body get rid of, if you will, cellular debris, that is causing the body’s immune system to be over expressive, I would think we’d have a synergistic complementary role to play.

I think, as a company, we always want to strive to have formulas that reflect, you know, where the cutting edge sciences, I think, you know, the end of the day, you know, the enzymes are always going to be the vanguard of what we’re about. But well, you know, it is worth noting, Dr. Rosen, because we are an actual actual manufacturer, will material manufacturer and Finnish manufacturer that often we do have, you know, formulators, developers, researchers that come to us to help them develop products.

So it’s certainly foreseeable that we could have somebody as we speak, who is who is in contact with a company that is doing something like that and but that’s what happens with our companies. We do have people, you know, with a real site, you know, with a real scientific, formulating bent that asks our company, because the interesting thing is to, in a number of our formulas that we use systemic enzyme formulas, we do use other ingredients, like we use, for instance, amla fruit.

In our systemic enzymes, it’s a very powerful sort of great source of vitamin C has antioxidant properties, we also use fulvic, minerals, ionic minerals. So we use things that have a complementary relationship, because often what people don’t realize, sometimes by enzymes is while they are classified as proteins, they’re often our CO enzyme components to enzymes. And so again, we make sure that that’s incorporated into the formulas. And because of that we have these long, long standing relationships often with suppliers, you know, where we can get these ingredients and make these formulas. So yeah,

Dr. Joel Rosen:
that’s great. That’s why I really liked the genomic testing that we do, because people say, Well, why, like, genes don’t dictate everything. And that’s true. We talked about epi genetics and stress and pathogens, and Wi Fi, and toxic metals and so forth, that cause the genes to express less or more.

But what the reason I like it, Jeff is because you can see sort of my mentor calls it a 3d chess game played underwater, where you can see these, these cofactors these inhibitors, these promoters, these upstream supporting stuff downstream supporting stuff.

And really, once you kind of get a lay of the of the of the blueprint, then you know what you can do to specifically support that, not just at that level reductionistic, we take this and it’s a magic wand, it fixes everything. But this is where maybe one of the the I guess the weak links in the chain is or where the build up is where we can try to help support that through a proper function.

And she ultimately your pain, your brain fog, your energy levels, your quality of life and prove which is, which is pretty cool. So I appreciate your insight on that. One of the questions I wanted to ask you, which I’m kind of curious about which you suggested we talk about is the Jekyll and Hyde of inflammation. So what did you mean by that? Yes.

Jeff Owen:
And that’s something that we actually, ASD enzymes talk about, in our focus on health booklets in our enzyme therapy guide. You know, inflammation is a term, you know, that people hear all the time, you know, it’s on their lips, often when they come into a health food store, they’re looking for, you know, something to help reduce their inflammation, like, like curcumin, as an example. Inflammation is your body’s natural response to an injury irritation or infection.

When the body is an example, if you’re in the kitchen, and you’re cutting an onion, and you cut yourself, you know, immediately what happens is there’s a cascade event of series of events that are going on in the body, to help protect yourself, you know, from that cut, so that you know, it doesn’t turn into something that’s life-threatening, your body actually starts emitting chemicals, you know, to the site of injury, it not surprisingly, you know, that area is usually hot to the touch.

That’s because of the fact that the body does that intentionally to help protect itself from invading microbes, the blood vessels become more porous, allowing the immune chemicals to come into the site of injury.

So inflammation is necessary, you know, to protect ourselves from you know, for an infection or cut a fever, and hopefully, you know, when the body is generally in a healthy state, the inflammation response will subside and resolve itself. But we’re seeing this phenomenon now in our society where it doesn’t, where the inflammation, you know, goes from an acute situation to one that is chronic and unceasing where the symptoms continue to perpetuate themselves to go on and on, and eventually if unresolved, it manifests itself in chronic disease, probably a good example would be like rheumatoid arthritis, where the body’s own healthy tissue is attacking itself, the body starts making over overexpressing pro-inflammatory, more markers like interleukin six, a tumor necrosis factor, and that becomes problematic.

People probably saw this themselves again, in the last three years with COVID where people’s immune systems went, when the inflammation response did not, you know, in essence, resolve itself. I remember seeing this one picture of a gentleman in a hospital where literally his, his lung tissue was just filled, filled, you know, with like fibrin type material and it was like his lung tissues were literally suffocating, resulting in double pneumonia.

And, obviously, you know, it was a very, very sobering situation for us as a society to see so many Americans, you know, succumbing to this illness and you know, I continue to read articles About people three years later, still having the symptoms of COVID and not entirely resolving themselves. So onethe one of the things that systemic enzymes can do is promote a more modulating, inflammation response, hoping to get the inflammation under contand rol manageable.

And again, because of the hallmark of what enzymes are being the bio catalyst, you know, breaking down dissolving those factors in the body that cause the inflammation to perpetuate themselves. So whether it’s debris, if you will, fibrin, the circulating factors in the bloodstream, which is why we feel as a company, that when you look at a whole range of chronic illnesses that are characterized by inflammation that is chronic, whether it’s autism, if you will, to uterine fibroids, Alzheimer’s disease, hypertension, fibromyalgia, lupus, all of these conditions, the getting the inflammation, you know, to be manageable, or hopefully, resolving itself is just critical. It’s critical.

Dr. Joel Rosen:
Yeah, absolutely. So, and I think it shouldn’t be understated that the digestive component is, is upstream from the systemic component, right, because if you’re not breaking down your foods, and you’re not extracting them, I talked about stepping on the grapes to make the wine, you know, if you’re not getting the juice out of the food that you’re eating, then you’re not gonna increase your ability to increase your supply for other demanders in the body as well.

And that’s, that’s a really important process for people. And I think because we cook, I call it cook the snot out of the food at such high temperatures. And it demands a lot of those gastric secretions of milking the cow, that you can’t keep up with that. And then that creates a vicious cycle of undigested food particles increased demand to have to break that down, further reduce supply, and then it just becomes this vicious cycle.

So thank you for much for sharing your your insights and your knowledge, with all the years that you’ve done this, I’m always excited to talk to people like yourself I say you went to the school of hard knocks, and you learned a lot of this stuff, through necessity, and talking to the reps and squeezing them for as much information as you can and talking to people and getting their feedback.

And, then, of course, the training and the research that your company provides and continues to, to expand upon. So thank you so much. I always like to ask the question, knowing what you know, now, Jeff, what are you doinge do you think is the most important information you would have told your younger self that perhaps would have helped you or accelerate, your healthy aging or slowed your rate of aging? What do you think would have been the best advice to your younger self?

Jeff Owen:
Oh, that’s a great conclusory question. Dr. Rosen, I think, knowing now what I didn’t know, t is understanding the inextricable relationship between digestive health and overall health, starting with, you know, eating the proper foods. I mean, we probably grew up in a similar culture, you know, with TV dinners, and, and, you know, foods and plastic wrap.

And, you know, our culture of course, you know, the thing about Americans spend an enormous amount of time thinking about food in the course of a day, you know, we’re bombarded with commercials about whateatting.

The thing is that when you watch food commercials, they never talk about the nutritive value because they don’t have any. So the thing that I really come to appreciate is how critically important food is, I always like to make an adage that the most powerful drug that there is this the foods we eat, it could be either your liberty or your prisoner. And then, now that I, you know, worked for this company for three years, you know, digestive health is so critical. So I think supplemental digestive enzymes can be such a powerful adjunct to people because when your digestive system is working more efficiently, and your body, as you said, it’s probably breaking down the foods and being able to absorb the nutrients, and then it has a salutary effect on your bowel health.

That has that anas an overall effect on all the organ systems in the body, whether it’s your cardiovascular system, your pulmonary system, your excretory, urinary system, everything, everything, your hormones, everything will be benefited. So people should understand, make the good, proper choices about food, eat, you know, eat a wholesome diet, minimally procesed, if you will stay away from those bad terrible seed oils that are so ever present in our food supply. And, you know, be cognizant of that, be cognizant of that.

And then and then probably typically as you get older, if after the age of 30, I would say you should definitely consider digestive enzyme supplementation of the fabric pack. The last thing I want to say this Dr. Rosen is one of the things I’m always amazed about, and particularly when I’m talking to senior citizens and health food stores, is how little protein they often get in their diet. And that’s another thing that people need to consider. You need to look at, you know, what, you know, in terms of what your food groups are, that you’re making sure you’re getting the adequate levels of protein, you know, healthy fats and carbohydrates. So people be conscious about food. Yeah, absolutely.

Dr. Joel Rosen:
I think I would echo that sentiment in terms of okay, well, I’m not feeling healthy, I’m exhausted, I’m tired. I feel like I’m rapidly aging. And I have a Santa Claus about a heck of supplements, right? A lot of people these do.

And I would say, well put them in categories and think about what you just said, in terms of, okay, am I getting good quality food, am I having both feet down sitting at a table, having as many bytes as I need, and I’m not on the go, and it’s not in fast food, or it’s not a five minute and not in the drive, I’m not driving, I’m sitting down, I’m digesting my food. And I’m squeezing it for all the nutrients that it’s giving me.

And if I need support digestive, ly, then I’m doing that too. And if you didn’t have a lot of disposable income to spend on a whole bunch of supplements, then digesting is going to be part of the number one, especially if we’re older. And getting that getting that diet food not only digesting for the nutrients that it’s giving you. But avoiding the undigested expense of it sitting there and fermenting and creating a whole slew of chemical signals that is going to rapidly aid you. So I appreciate your time.

Jeff, thank you so much for being here. And for anyone that’s interested in learning more about your company and the different products that you have, I’ll have a link underneath the show notes so that they can do that. And I thank you for your time today. Jeff, thank you for sharing your knowledge.

Jeff Owen:
Thank you so much for having me, Dr. Rosen. It’s it’s been a real privilege.

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